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Invitrogen
Complement C5b Monoclonal Antibody (aE11)
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产品信息
DIA 011-01-02
应用
建议稀释比
已发表文章
产品规格
种属反应
Horse,
Human,
Non-human primate,
Pig
已发表种属
C. elegans,
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
aE11
抗原
Purified C5b-9.
偶联物
形式
Liquid
浓度
1.00 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
4°C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
DIA 011-01-02 binds both membrane-bound MAC and fluid-phase SC5b-9 complexes from human, porcine, baboon and equine samples.
DIA 011-01-02 has been successfully used in ELISA and IHC applications. This antibody is not recommended for Western blotting as the epitope is destroyed during the process.
靶标信息
C5b-9 is also known as the TCC. TCC consists of C5b, C6, C7, C8 and C9. The complex forms transmembrane channels which displace lipid molecules and other constituents, thus disrupting the phospholipid bilayer of target cells leading to cell lysis by osmotic leakage. The complex contains neoantigens that are absent from the individual native components and the monoclonal antibody DIA 011-01 is directed against a neoepitope exposed in C9 when incorporated into TCC.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; C5a anaphylatoxin; CHE1; Complement C5; complement component C5; FLJ17816; FLJ17822; MGC142298; prepro-C5
基因别名: C5; C5a; C5b; C5D; CPAMD4; ECLZB
UniProt ID: (Human) P01031
Entrez Gene ID: (Human) 727, (Horse) 100067655, (Pig) 414437
activation of MAPK activity
in utero embryonic development
chemotaxis
response to stress
inflammatory response
complement activation
complement activation, alternative pathway
complement activation, classical pathway
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of vascular endothelial growth factor production
negative regulation of macrophage chemotaxis
negative regulation of endopeptidase activity
cytolysis
regulation of complement activation
positive regulation of angiogenesis
cell chemotaxis
positive regulation of chemokine secretion
mitophagy in response to mitochondrial depolarization
